I just recently discovered that there is a national holiday named after Atheism. April FOOLS day. Like this story in the name of Jesus.
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Take a squirt gun into the rest room stall next to someone and shoot little drops over the wall every couple of seconds while pretending to pee.
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Hide all of the desktop icons on someone's computer and replace the monitor's wallpaper with a screen-shot of their desktop.
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Write a message on an upside-down paper cup that alludes to something horrible being trapped under it. Leave it on a coworker's desk or in a conference room.
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Fill someone's hair-dryer with baby powder.
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